Maternal rheumatoid arthritis linked to childhood epilepsy

 

Rheumatoid arthritis is an autoimmune disease whereby the body's own immune system attacks the joints. New research suggests there may be a link between mothers with the autoimmune disorder and their children who develop epilepsy.

Rheumatoid arthritis in the mother may lead to childhood epilepsy, study suggests.

Rheumatoid arthritis (RA) is an autoimmune condition characterized by inflammation of the joints. It is different from osteoarthritis, which is caused by wear and tear in the joints.
RA affects up to 1.3 percent of the worldwide population, according to the Centers for Disease Control and Prevention (CDC). In the United States in 2005, 1.5 million adults over 18 years old were diagnosed with RA, and the CDC report that the numbers may currently be on the rise.
While there is no known cure for RA, one study found that 75 percent of people with RA experienced remission within the first 5 years of being diagnosed.
Epilepsy is a neurologic disorder consisting of recurrent epileptic seizures that are sometimes of unknown origin. According to the CDC, about 5.1 million people in the U.S. have been diagnosed with epilepsy or have had a seizure disorder. Of these, 2.9 million adults have active epilepsy.
Previous research has connected the presence of an autoimmune disorder in mothers with the risk that the child develops epilepsy. New research looks at the link between RA and epilepsy.

Mothers with RA linked to children with epilepsy

A new study led by Ane Lilleore Rom, Ph.D., of Copenhagen University Hospital in Denmark, examines the link between mothers with RA and the incidence of epilepsy in their children.
Researchers looked at the clinical records of almost 2 million children born in Denmark between 1977-2008. The children were then followed up for an average of 16 years. Diagnoses of RA and epilepsy were obtained from the Danish National Hospital Registry.
A total of 13,511 children from the studied cohort had mothers with RA. The number included mothers who were diagnosed with rheumatoid arthritis after their child was born, as they were considered to have "preclinical" PA.
Of these, 31,491 children, or 1.6 percent, developed epilepsy over the 16-year period.
Children whose mothers had RA at the time they were born were 90 percent more likely to develop epilepsy than children whose mothers were healthy, while children whose mothers had preclinical RA also had a 30 percent higher risk of developing epilepsy than mothers without the condition.
The study did not find any effect on whether the child would have epilepsy if the father had RA.
The researchers say the association between preclinical RA and increased epilepsy risk in offspring suggests it is likely RA itself that is to blame, rather than treatments for epilepsy.
The results also remained unchanged after adjusting for other factors, such as the baby's birth weight, the mother's age at birth, and if the mother also had epilepsy.
The results are published in Neurology - the journal of the American Academy of Neurology.

Significance of results and further research

According to Rom, previous research has already found an increased risk of epilepsy in people with autoimmune diseases that involve the brain directly, such as multiple sclerosis (MS) or autoimmune encephalitis.
"But it is new knowledge that also offspring of mothers with rheumatoid arthritis seem to have an increased risk of developing epilepsy," Rom says.
Recently, other autoimmune and inflammatory disorders have been associated with seizures and epilepsy, such as systemic lupus erythematosus, ulcerative colitis, and type 1 diabetes.

"These results suggest that changes in the environment for the fetus may play a role in the development of epilepsy. We don't know yet how this may work, but it could involve the production of maternal antibodies that could affect the unborn child."

Ane Lilleore Rom, Ph.D.

However, researchers point out that more research is needed to look into the consequences of RA treatment.
Also, the study only showed an association between the RA and epilepsy, so further research is needed to confirm causality and explain exactly how RA in the mother might affect the chances of offspring having epilepsy.
Learn about how stress increases seizures for patients with epilepsy.

Written by Ana Sandoiu

 Rheumatoid arthritis is a chronic inflammatory disorder that can affect more than just your joints. In some people, the condition also can damage a wide variety of body systems, including the skin, eyes, lungs, heart and blood vessels.
An autoimmune disorder, rheumatoid arthritis occurs when your immune system mistakenly attacks your own body's tissues.
Unlike the wear-and-tear damage of osteoarthritis, rheumatoid arthritis affects the lining of your joints, causing a painful swelling that can eventually result in bone erosion and joint deformity.
The inflammation associated with rheumatoid arthritis is what can damage other parts of the body as well. While new types of medications have improved treatment options dramatically, severe rheumatoid arthritis can still cause physical disabilities.

Mangosteen juice: Can it relieve arthritis pain?

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Can drinking mangosteen juice reduce arthritis inflammation and pain?

Answers from Brent A. Bauer, M.D.

It might. A number of laboratory and animal studies suggest that mangosteen has significant anti-inflammatory effects. And a few small-scale studies in humans indicate that the juice helps reduce blood levels of C-reactive protein (CRP). CRP is a substance associated with inflammation, which may be caused by widespread infection or disorders such as inflammatory bowel disease, lupus and rheumatoid arthritis.
But the studies that found this reduction in CRP were not conducted with people who have arthritis. And not everybody who has arthritis has elevated CRP. So at this point, while the data appears promising, it's too early to say what role mangosteen juice has in treating arthritis symptoms.
Mangosteen is a tropical fruit native to Southeast Asia. Despite its name, mangosteen is not related to the mango. The mangosteen fruit is the size and shape of a tangerine, with a thick, dark rind and creamy flesh. Mangosteen is marketed as a supplement, both as a juice and in capsule form.